Wright Lab
Neurogenomics Research

Hello there, welcome to the Wright Lab! We are a human genetics research group at the University of Manitoba that uses genomics to understand the brain in health and disease.

We would like to understand why individuals affected by the same neurological disorder can experience differences in disease severity and onset.

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<span style="color:#F2A900">**Wright Lab**</span>  
  <span style="color:#7BAFD4">Neurogenomics Research</span>

Genetic variants that alter the clinical expression of disease-causing mutations are known as genetic modifiers and can help explain differences in disease outcomes. For example, genetic variants in genes from DNA repair pathways influence age-of-onset for several neurological diseases.

We use large-scale bioinformatic analyses to inform functional genomic experiments. This includes using gene editing and human stem-cell-derived neural models to study genetic modifiers of neurological disorders.

Insights obtained from our research can lead to a better understanding of human biology, the identification of therapeutic targets, and improved risk prediction models.


  • Genetic modifiers of neurological disorders
  • Genomics of DNA repair in the brain

What we do

We use both wet and dry lab approaches to understand human biology

Key Disorders

• Huntington disease
• Rett syndrome

Key Computational Methods

• Genomic fine mapping
• Single-cell sequencing
• Machine learning

Key Wet Lab Methods

• Human stem cells
• Neural cell culture
• CRISPR gene editing


Territory acknowledgement: Our research group is located on the original lands of Anishinaabeg, Cree, Oji-Cree, Dakota and Dene peoples, and on the homeland of the Métis Nation. We respect the Treaties that were made on these territories, we acknowledge the harms and mistakes of the past, and we dedicate ourselves to moving forward in partnership with Indigenous communities in a spirit of reconciliation and collaboration.

We are primarily affiliated with the Department of Pharmacology & Therapeutics at the University of Manitoba. Our lab is in the Neuroscience Research Program at the Kleysen Institute for Advanced Medicine, Health Sciences Centre. We are also affiliated with the Department of Biochemistry and Medical Genetics, as well as the Children’s Hospital Research Institute of Manitoba (CHRIM, ENRRICH theme).


Latest News

If you interested in joining the lab as a trainee, please see key information in our Contact section.